Animal Models in Cancer Chemoprevention

Animal Models of Colorectal Cancer in Chemoprevention and Therapeutics Development

Considering the complexity of genetic and epigenetic events that occurs during colorectal carcinogenesis and the uncertainty in relying solely on extrapolation from cell culture models, it is essential to use animal models relevant to the molecular characteristics of colorectal cancer (CRC). Requirements for a mouse model of CRC are that the model has relevance to the molecular pathways involve...

Preclinical Animal Models for the Development of Cancer Chemoprevention Drugs

Challenges in prostate cancer research: animal models for nutritional studies of chemoprevention and disease progression.

Prostate cancer is the second leading cause of cancer-related death in the United States. The American Cancer Society estimates that there will be over 232,000 new cases of prostate cancer in 2005. Evidence suggests that diet can act as a chemopreventive agent to reduce the incidence of prostate cancer as well as to reduce the mortality of the disease. Epidemiologic studies suggest that diets r...

Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention.

Coxibs, including celecoxib, and other nonsteroidal anti-inflammatory drugs (NSAID), including aspirin, are among the most promising cancer chemopreventive agents in development today. This article examines the data on the efficacy of these agents in animal model studies of cancer prevention carried out by the authors. The studies evaluated here are restricted to our rodent models of colon/inte...

P-170: Animal Models of Human Artificial Ovary, Valuable Tools for Fertility Preservation in Cancer Patients

Background: With all the recent advances in cancer treatments, many young cancer patients find themselves facing the prospect of losing their fertility after aggressive chemotherapy or radiotherapy. Cryopreservation of ovarian cortical tissue has emerged as a potential option to restore fertility in these young women. Materials and Methods: Because autotransplantation of cryopreserved ovarian c...